PROPERTIES

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

14, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (224M-14)
vial of 0.5 mL concentrate (224M-15)
bottle of 1.0 mL predilute (224M-17)
vial of 1.0 mL concentrate (224M-16)
bottle of 7.0 mL predilute (224M-18)

manufacturer/tradename

Cell Marque^™

concentration

1.0-5.0 μg/mL (predilute)
25-125 μg/mL (concentrate)

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG1

control

fibromatosis of breast

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous, nuclear

DESCRIPTION

General description

Beta-Catenin is a 92 kD protein normally found in the cytoplasm of the cell in the submembranous location. This protein is associated with E-Cadherin and may be essential for the function of E-Cadherin. Mutations in the Beta-Catenin gene result in nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in fibromatosis lesions of the breast and abdomen and therefore is useful in differentiating this lesion from other spindle cell lesions that may occur in these locations. Nuclear accumulation of Beta-Catenin has also been demonstrated in colorectal carcinoma.