Benzo[a]pyrene ?96% (HPLC)

?96% (HPLC)

Synonym(s):3,4-Benzopyrene, 3,4-Benzpyrene, Benzo[def]chrysene

Properties

Quality Level

200

assay

?96% (HPLC)

form

solid

bp

495??C (lit.)

mp

177-180??C (lit.)

SMILES string

c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45

InChI

1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H

InChI key

FMMWHPNWAFZXNH-UHFFFAOYSA-N

Description

Application

Benzo[a]pyrene (PAH), a polycyclic aromatic hydrocarbon pollutant, is used as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on it?s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.

Packaging

100, 250, 500 mg in glass bottle1, 5 g in glass bottle

Safety Information

Pictograms

GHS07,GHS08,GHS09

Signal Word

Danger

Hazard Statements

H317 – H340 – H350 – H360FD – H410

Precautionary Statements

P202 – P261 – P273 – P280 – P302 + P352 – P308 + P313

Hazard Classifications

Aquatic Acute 1 – Aquatic Chronic 1 – Carc. 1B – Muta. 1B – Repr. 1B – Skin Sens. 1

Storage Class Code

6.1C – Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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